Abstract # 2433 Radiation Morbidity In Cancer Patients May Be Predicted By The Micronucleus Assay

Presenter: Lee, Tung-Kwang

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About the Presenter:
Grant NIH/NCCAM - Lee TK (PI), Johnke RM (CI), O’Brien KF (Collaborator), Allison RR (Consultant), R21-AT002639-01A1, Title: Radioprotective Potential of Ginseng. Award Amount: $320,626 (09/01/2005 – 08/31/2007) Selected Publications and Presentations: See More on PubMed>> Lee TK, Johnke RM, Allison RR, O’Brien KF, Dobbs LJ, Radioprotective potential of ginseng. Mutagenesis 2005, 20:237-243. Lee TK, Allison RR, O’Brien KF, Johnke RM, Wiley AL, Jr. Karlsson UL, Arastu H. Radiotherapy-induced micronuclei in lymphocytes of 107 cancer patients is associated with radiation morbidity. American Association for Cancer Research, 96th Annual Meeting, April 17, 2005, Anaheim, CA. Lee TK, Allison RR, O’Brien KF, Khazanie PG, Johnke RM, Brown R, Bloch RM, Tate ML, Dobbs LJ, Kragel PJ. Ginseng reduces the micronuclei yield in lymphocytes after irradiation. Mutation Research 2004, 557:75-84. Lee TK, Allison RR, O’Brien KF, Johnke RM, Kovacs CJ, Karlsson UL, Micronuclei may predict radiotherapy-induced morbidity in prostate cancer patients. American Association for Cancer Research, Proceedings of the 95th Annual Meeting, Vol. 45 (Abstract #3128), 2004. Lee TK, Allison RR, O’Brien KF, Johnke RM, Kovacs CJ, Tate ML, Karlsson UL, Wiley AL, Jr. Micronuclei in lymphocytes may predict radiation morbidity in patients with solid tumors. Int J Radiat Oncol Biol Phy 2004, 60 :S368. Lee TK, Allison RR, O’Brien KF, Kovacs CJ, Kalika S. Radioprotection of WR-1065 on human lymphocytes. The Cancer J 2004, 10 (Sup. 1):44. Lee TK, Allison RR, O’Brien KF, Johnke RM, Kovacs CJ, Tate ML, Karlsson UL, Wiley AL, Jr. Intrinsic radiosensitivity determined by micronuclei production in lymphocytes; correlation with radiation morbidity in patients with malignancies of lung, and head and neck. Lung Cancer 2004, 46 (Sup. 1):S46-S47. Lee TK, Allison RR, O’Brien KF, Johnke RM, Christie KI, Naves JL, Kovacs CJ, Arastu H, Karlsson UL. Lymphocyte radiosensitivity correlated with pelvic radiotherapy morbidity. Int J Radiation Oncol Biol Phys 2003; 57: 222-229. Fenech M., Bonassi S, Turner J, Ceppi M, Chang WP, Holland N, Lee TK, et al. Intra - and inter-laboratory variation in the scoring of micronuclei: and nucleo- plasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project. Mutation Research 2003; 534:45-64. Lee TK, Allison, RR, O’Brien KF, Naves JL, Karlsson UL, Wiley AL.Jr. Persistence of micronuclei in lymphocytes of cancer patients after radiotherapy. Radiation Research 2002; 157:678-684 Bonassi S, Fenech M, Lando C, Lin Y-P, Ceppi M, Chang WP, Holland N, Lee TK, et al. Human micronucleus project: International database comparison for results with the cytokinesis-block MN assay in human lymphocytes: 1. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of MN. Environmental and Molecular Mutagenesis 2001; 37:31-45. Lee TK, O’Brien KF, Naves JL, Christie KI, Wiley AL, Jr; Karlsson UL. Micronuclei in lymphocytes of prostate cancer patients undergoing radiation therapy. Mutation Research 2000; 469:63-70. Lee TK, O’Brien KF, Eaves GS, Christie KI, Varga L. Effect of blood storage on radiation-induced micronuclei in human lymphocytes. Mutation Research 1999; 444:201-206 Lee TK, O'Brien KF, Karlsson UL, Christie K, Wiley AL Jr. Effect of ex vivo hyperthermia on radiation-induced micronuclei in Iymphocytes of cancer patients before and during radiotherapy. Mutation Research 1998; 417:1-8. “Lymphocyte Radiosensitivity is Correlated with Pelvic Radiotherapy Morbidity”, The 44th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), New Orleans, LA, October 9, 2002. “Ginseng Reduced the MN yield in Lymohicytes After Irradiation”, The 49th Annual Meeting of the Radiation Research Society, April 21, 2002, Reno, Nevada. “Biodosimetric assessment of MN in Lymphocytes of Patients With Pelvic RT”, The 43rd Annual Meeting of ASTRO, November 5, 2001, San Francisco, CA. Ed Warren Life Sciences 002 The Brody School of Medicine Greenville, NC 27858-4354 Telephone: (252) 744-3768 Fax: (252) 744-3775 Email: leet@mail.ecu.edu
Contact the presenter at: leet@mail.ecu.edu

Authors:
Lee, Tung-Kwang (1) ; Allison, Ron R (1) ; O'Brien, Kevin F (2) ; Johnke, Roberta M (1) ; Karlsson, Ulf L (1) ; Arastu, Hyder (1) ; Wiley, Jr., Albert W (1) .

Institutions:
1. Radiation Oncology, Brody Sch. Med. at ECU, Greenville, NC, USA.
2. Biostatistics, ECU Sch. Allied Health, Greenville, NC, USA.

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