Abstract # 1019 Improvement in Vision and Cranial Neuropathies after Stereotactic Radiotherapy for the Treatment of Skull Base Meningiomas

Presenter: McElveen, Tracy

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Two hundred and thirty nine patients were treated with fractionated stereotactic radiosurgery for meningiomas at the Jefferson Hospital for Neurosciences between 1994 and 2002. Of these patients, 118 had tumors located in the anterior skull base. All patients were immobilized using a GTC relocatable frame and underwent CT-MRI fusion for treatment planning. The mean target volume was 11.7cc (range 0.7 - 45.1cc). Patients were treated with a dedicated 6 MV linear accelerator using circular collimators directed in noncoplanar arcs with an average of 2.6 isocenters (range 1 - 7). Dose was delivered in 1.8 Gy fractions to a median cumulative dose of 54.0 Gy (range, 9.0 - 56.0 Gy), during a 5-week period. The median follow-up time was 32 months (range 7 - 96 months). Patients were examined and imaged with MRI during the first 3 months after receiving SRT and every 6 months thereafter. Baseline cranial neuropathies were evaluated clinically and characterized as stable, improved, resolved or progressive in the follow-up period. Pre- and post-radiotherapy serial radiographic evaluations, including MRI scans were compared to establish objective tumor response and local control.

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