Abstract # 2047 Ki-67 Proliferation Index as a Marker for Clinical Radioresponse in Glioblastoma Multiforme

Presenter: Abacioglu, Ufuk

< Back to topics

> Cover Page, Authors, Institutions

> Purpose/Objective

> Materials/Methods

> Results

> Conclusions

> View tables/images/videos

Patients were treated in a single institution between 1997 and 2004. Median age was 59 years (range 22-79) and male/female ratio 55/30. KPS score ranged between 30 and 100 (median 80). Median duration of symptoms was 1 month (1-84 months) and 27% had a history of convulsions. Multicentricity was present in 13% and the median tumor diameter was 4 cm (1.5-7 cm). Type of surgery was gross total resection in 43%, subtotal resection in 29% and stereotactic biopsy in 28%. All patients received median dose of 60 Gy radiotherapy (range 10-72 Gy). MIB-1 (MS-123-R7, Neomarkers) against the Ki-67 antigen in paraffin-embedded tissue sections was used to determine Ki-67 PI. Overall survival (OS) curves were plotted by Kaplan-Meier method, and differences were calculated by log-rank test. Multivariate analysis of prognostic factors was performed by Cox regression analysis.

Click on images to enlarge (a new pop-up window will open)

Abstracts main page