Abstract # 2274 A Prospective Study of Radiation Induced Lung Injury: Measured Changes in Pulmonary Symptoms, Physiologic Function and CT Density

Presenter: Lee, Justin

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Patients treated with radical or adjuvant radiotherapy(RT), where a portion of the lung was in the radiation field, were eligible for the study. Pulmonary symptoms were assessed prior to RT, 1 month and 3 months post-RT using the NCI CTC version 2.0, then at 6 months using the RTOG late radiation morbidity score. Pulmonary function tests (PFT) and CT planning scans in the treatment position were performed prior to RT then at 3 and 6 months post-RT. An algorithm was developed in-house to measure the CT density of normal lung tissue within the high dose volume as defined by the beam edges, excluding the primary tumour and atelectasis. The mean lung density as expressed in Hounsfield Units (HU) was then derived by a volumetric averaging of the voxels within the high dose region.

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