Abstract # 2361 Preliminary Report of Proton Radiotherapy for Pediatric Low-Grade Gliomas

Presenter: Yock, Torunn

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Twenty-two patients were identified with low-grade (WHO grade I or II) gliomas and treated with predominantly proton radiation therapy from 1995 to 2004 at the HCL, a 160 MeV fixed beam unit, or at the NPTC, a 240 MeV gantry system. Due to an RBE of 1.1, 1.64 Gy of proton radiotherapy was used to achieve the same effect as 1.8 Gy of Cobalt Radiation. We report our experience using Cobalt Grey Equivalent dose (CGE). Tissue was reviewed and confirmed by the neuropathology service at MGH when available. In three cases, diagnoses were made based on imaging findings only. Twelve patients received chemotherapy and/or surgery and either progressed or recurred prior to definitive radiation therapy. Actuarial overall survival (OS) and progression-free survival (PFS) were both determined by the Kaplan-Meier method. Ten (45%) patients were treated with a combination of photon and proton treatments with 10-30% of the dose given with conformal 3-D photon radiation due to scheduling constraints on the HCL at that time. Twelve (55%) patients were treated with proton therapy alone. Baseline neurocognitive studies were not obtained routinely until 2004.

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