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Surgical clips placed in the lumpectomy cavity are potentially useful in image-guided treatment of breast cancer, particularly external beam accelerated partial breast irradiation (APBI). Previous work has argued that a) the likely benefit of using clips for localization is substantial and worth pursuing, and b) online localization is clinically feasible from the viewpoint of time, equipment, and process. Here we give results from our clinical experience with online localization, further evaluate the accuracy of clip-based guidance, and offer a preliminary calculation of achievable setup margin.
D. Weed et al., "The validity of surgical clips as a radiographic surrogate for the lumpectomy cavity in image-guided accelerated partial breast irradiation," IJROBP v. 60 no. 2 (2004), 484-492.