Abstract # 2392 The Identification of Mre11 as the Central Participant in Multiple Subpathways of Repairing Chromosomal Double-StrandBreak

Presenter: Zhuang, Jing

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Germline mutation of Mre11 is the cause of Ataxia telangiectacia-like disease (ATLD). ATLD Patients share similar clinic presentations with AT patient. Mre11, in a complex with Rad50 and NBS1, plays an important role in DNA damage sensing and signaling. Loss of Mre11 resulted in increased radiosensitivity and chromosomal instability. It is not clear that Mre11 is involved in the process of repair chromosomal double-strand breaks (DSBs). The function of Mre11in homologous recombination (HR) is indicated only in yeast. But, its role in non-homologous end-joining (NHEJ) is controversial. Here, we systemically define the function of human Mre11 protein in the four major DSB repair subpathways in chromosomal context.

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