Abstract # 2270 Prospective Assessment of Models to Predict Radiation Pneumonitis Based on Dosimetric/Functional Parameters

Presenter: Kocak, Zafer

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Overall, 21/62 patients developed RP. The relationship between the pre-RT pulmonary function (y-axis), MPLD (x-axis) and RP are shown in the figure. High risk was defined prospectively as an MPLD (or MLD) >25 Gy or an MPLD and pre-RT DLCO that lie below the reference line shown in the figure. The rates of RP in the high and low risk groups were 14/40 and 7/22, respectively (p=0.51, one tailed Fishers). Thus, for the overall group, the prospective model was not predictive. However, there appears to be an interaction between the pre-RT PFTs and the ability to predict RP. In the patients with pre-RT DLCO>60%, MLD >20 Gy (11/24 vs. 1/18, p=0.005) and MPLD >25 Gy (4/6 vs. 8/34, p=0.05) were predictive for RP.

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